Insights from Antarctica to the Clinic: Novel Staphylococcus species and their mobile genetic arsenal
Location
Gallaudet University - JSAC Multipurpose Room
Start Date
5-3-2024 10:00 AM
End Date
5-3-2024 10:30 AM
Description
Coagulase-negative species of the genus Staphylococcus (CoNS) are found in various environments, and as opportunistic pathogens, they often cause bloodstream and implant biofilm-related infections, especially in immunocompromised patients. The study of CoNS is crucial due to its role as a reservoir of antibiotic resistance determinants located on mobile genetic elements. Recently, next-generation sequencing has become more accessible and has enabled the use of in-depth genome analysis for the study of the evolution of genomes and accurate species identification. Here, we present descriptions of three novel CoNS species, each representing a distinct phylogenetic branch within the genus: Staphylococcus edaphicus from Antarctic soil, Staphylococcus ratti from laboratory rat, and Staphylococcus brunensis from human clinical material. The presented results are part of the dissertation thesis and will focus on the analysis of novel mobile genetic elements, including a unique genome island designated SbCIccrDE. This island contains a recombinase gene complex, an essential part of SCCmec, which confers resistance to methicillin, and its spread into the human pathogen Staphylococcus aureus significantly impacts healthcare. The comparative genomic analysis has shown the potential to accumulate virulence and drug resistance factors and helps to understand the evolution of SCC-like elements.
Recommended Citation
Kovarovic, Vojtech, "Insights from Antarctica to the Clinic: Novel Staphylococcus species and their mobile genetic arsenal" (2024). Global Year of STEM Sign Language. 4.
https://ida.gallaudet.edu/global_STEM_signlanguage/STEM_signlanguagesummit/day_4/4
Insights from Antarctica to the Clinic: Novel Staphylococcus species and their mobile genetic arsenal
Gallaudet University - JSAC Multipurpose Room
Coagulase-negative species of the genus Staphylococcus (CoNS) are found in various environments, and as opportunistic pathogens, they often cause bloodstream and implant biofilm-related infections, especially in immunocompromised patients. The study of CoNS is crucial due to its role as a reservoir of antibiotic resistance determinants located on mobile genetic elements. Recently, next-generation sequencing has become more accessible and has enabled the use of in-depth genome analysis for the study of the evolution of genomes and accurate species identification. Here, we present descriptions of three novel CoNS species, each representing a distinct phylogenetic branch within the genus: Staphylococcus edaphicus from Antarctic soil, Staphylococcus ratti from laboratory rat, and Staphylococcus brunensis from human clinical material. The presented results are part of the dissertation thesis and will focus on the analysis of novel mobile genetic elements, including a unique genome island designated SbCIccrDE. This island contains a recombinase gene complex, an essential part of SCCmec, which confers resistance to methicillin, and its spread into the human pathogen Staphylococcus aureus significantly impacts healthcare. The comparative genomic analysis has shown the potential to accumulate virulence and drug resistance factors and helps to understand the evolution of SCC-like elements.
Comments
The video is nonexistent due to there being an error on the technical side of recording the events.